In vivo Effects of CortiNon+ on the Emergence and Progression of Experimental Graffi Tumor in Hamsters
Reneta Toshkova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences (BAS). Sofia, Bulgaria.
Ignat Ignatov *
Scientific Research Center of Medical Biophysics. Sofia, Bulgaria.
Elisaveta Zvetkova
Bulgarian Association of Bioreology, Institute of Mechanics, Bulgarian Academy of Sciences (BAS), Sofia, Bulgaria.
Georgi Gluhchev
Institute of Information and Communication Technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Georgi Dinkov
IDEALABS, Limited Liability Company (LLC), Washington 20036, USA.
*Author to whom correspondence should be addressed.
Abstract
Results from a three arms pilot study on the preventive and therapeutic effects of the food supplement CortiNon+ on the development of Graffi myeloid tumor in hamsters have been presented. Biometric parameters of tumor growth and peripheral blood count were evaluated. Two schemes of experimental oral formulation of antitumor therapy were applied ne started 7 days before tumor transplantation and a second one that started simultaneously with the tumor transplantation. The control 3rd group did not receive any oral supplementations. The results demonstrated protective antitumor effect of CortiNon+, expressed by decrease of transplantability and lowering lethality, inhibition of tumor growth and increase of survival rate of the treated animals compared to the untreated ones. The efficacy of the experimental therapy was more pronounced when it was started 7 days before transplantation of the tumour cells. Also, differences in hematological parameters were registered between the groups. Presented results suggest that CortiNon+ is a promising drug candidate for treatment of haematological malignancies
Keywords: Graffi myeloid tumor, cortinon therapy, tumor growth parameters