Evaluation of Abdominal Aortic Bifurcation Level in Pelvic Cancer Patients Undergoing Radiotherapy: A Retrospective CT Based Analysis

Shiva Divya *

Department of Radiation Oncology, Lakhimpur Cancer Centre, A unit of Government of Assam and Tata Trusts Initiative, India.

*Author to whom correspondence should be addressed.


Abstract

Indroduction: This retrospective study aims to investigate the implications of the bifurcation of the abdominal aorta on radiation therapy planning for cervical cancer patients, within the broader context of assessing CT scans of various pelvic malignancies.

Methods: Patients who undergone radiotherapy for pelvic cancers between 2022 and 2024 were included in this retrospective study. The cohort comprised individuals diagnosed with cervical cancer, rectal cancer, and other pelvic malignancies. All patients undergone adequate immobilization in the supine position and received contrast-enhanced computed tomography (CT) simulation for radiotherapy planning, following a standardized bladder protocol. The level of division of the abdominal aorta into the right and left common iliac arteries, relative to the vertebral level, was determined and studied.

Results: In our study of 40 pelvic cancer patients, the division of the abdominal aorta into common iliac arteries primarily occurred above and at the level of the L3-L4 intervertebral space in 52.5% (21/40) of cases, in front of the body of the L4 vertebra in 25% (10/40) of cases, and at the L4-L5 intervertebral space in 22.5% (9/40) of cases.

Conclusion: The division of the abdominal aorta typically occurs at a higher level than the L4-L5 intervertebral space level in pelvic cancer patients. Our findings underscore the importance of utilizing CT scan-based planning for radiotherapy to accurately target treatment areas. However, in facilities where CT-based planning is unavailable, it is recommended to shift the upper border of the radiotherapy treatment portal above the L3-L4 intervertebral space for cervical cancers for optimal coverage of the iliac lymph node chain. These recommendations aim to ensure adequate radiation dose delivery while considering anatomical variations in pelvic cancer patients.

Keywords: Abdominal aorta, common iliac arteries, pelvic cancers, radiotherapy planning anatomical variations


How to Cite

Divya, Shiva. 2024. “Evaluation of Abdominal Aortic Bifurcation Level in Pelvic Cancer Patients Undergoing Radiotherapy: A Retrospective CT Based Analysis”. International Research Journal of Oncology 7 (1):123-30. https://www.journalirjo.com/index.php/IRJO/article/view/154.

Downloads

Download data is not yet available.

References

Viswanathan AN. Uterine Cervix. In: Halperin EC, Wazer DE, Perez CA, Brady LW, (eds). Perez and Brady’s Principles and Practice of Radiation, 7th ed. Philadelphia: Wolters Kluwer. 2018;5169-5218

Taylor A, Rockall AG, Powell MB. An Atlas of the Pelvic Lymph Node Regions to Aid Radiotherapy Target Volume Definition. Clin Oncol. 2007;19: 542-45

Int J Radiat Oncol Biol Phys. 2019;105(1, Suppl): E337-E338.

Kumar Padhy A, Abarajda V, Nayak R, L. Nayak B, Mohapatra J, Samantaray S. Analysis of Pelvic Lymph Nodal Metastasis in Operable Cases of Cancer Cervix-A One Year Cohort Study at a Regional Cancer Centre. J. Can. Tumor Int. 2016;4 (3):1-7. Available:https://journaljcti.com/index.php/JCTI/article/view/70 [Accessed on 2024 May 15].

Pellizzon ACA, Fogaroli RC. Outcomes of Patients with Unfavorable Prostate Cancer Treated with High-Dose Rate Brachytherapy and External Beam Radiotherapy. J. Adv. Med. Med. Res. 2013;3(4):2256-68. [Accessed on 2024 May 15]. Available:https://www.journaljammr.com/index.php/JAMMR/article/view/4810

Healy JC, Borley NR. Gray’s Anatomy - The Anatomical Basis of Clinical Practice. 39th ed. Philadelphia, USA: Elsevier Churchill Livingstone Publishers. 2005;1113–26.

Rosse C, Rosse PG, editors. Hollinshead’s Textbook of Anatomy. 5th ed. Philadelphia, USA: Lippincott-Raven Publishers.1997;600.

Romanes GJ, editor. Cunninghams Manual of Practical Anatomy. Thorax and Abdomen. 15th ed. New York, USA: Oxford University Press; 1986;2:175.

Bergman RA, Afifi AK, Miyauchi R. Abdominal Aorta. In: Illustrated Encyclopedia of Human Anatomic; 1986. Variation. Anatomy Atlases. 2012. Available:http://www.anatomyatlases.org/AnatomicVariants/Cardiovascular/Text/Arteries/AortaAbdo minal.shtml.

Prakash, Mokhasi V, Rajini T, Shashirekha M. The abdominal aorta and its branches: anatomical variations and clinical implications. Folia Morphol (Warsz). 2011;70(4):282–86.

Rai B, Bansal A, Patel F, Gulia A, Kapoor R, Sharma SC. Pelvic Nodal CTV from L4-L5 or Aortic bifurcation? An Audit of the Patterns of Regional Failures in Cervical Cancer Patients Treated with Pelvic Radiotherapy. Jpn J Clin Oncol. 2014;44:941-947.

Mishra H, Hadi R, Sahni K, Mishra R, Ali M. Evaluation of Level of Aortic Bifurcation in Patients of Carcinoma Cervix. Ann Int Med Den Res. 2017;3:RT01-RT03.

Ponni TR, Avinash HU, Janaki MG, Koushik AS, Somashekar MK. Implication of Bifurcation of Abdominal Aorta for Radiotherapy Planning for Cervical Cancers. J Clin Diagn Res. 2015;9: XC01-XC03.

Beadle BM, Jhingran A, Yom SS, Ramirez PT, Eifel PJ. Patterns of regional recurrence after definitive radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2010;76(5):1396–403. PubMed PMID: 20133069.

Tamaki T, Ohno T, Kiyohara H, Noda SE, Ohkubo Y, Ando K, et al. Carbon-ion radiotherapy for marginal lymph node recurrences of cervical cancer after definitive radiotherapy: a case report. Radiat Oncol. 2013;8:79. PubMed PMID: 23517664; PubMed Central PMCID: PMC3622111.

Benedetti-Panici P, Maneschi F, Capelli A, Scambia G, Greggi S, Cutillo G, et al. Lymphatic spread of cervical cancer: an anatomical and pathological study based on 225 radical hysterectomies with systematic pelvic and aortic lymphadenectomy. Gynecol Oncol. 1996;62(1): 19–24.

Gautam D, Baral S, Sharma N. Importance of aortic bifurcation for pelvic radiotherapy in cervical cancer patients. Nepalese Journal of Cancer. 2022;6(1):28–33.

Bera A, Maji A, Debasmita Chakrabarti, Adhikary S, Manna D, Gangopadhyay S, Mandal S. The bifurcation level and geometric anatomy of abdominal aorta – Does it matter in cervical malignancy? Experience from tertiary cancer center. Asian J Med Sci. 2024;15(4): 8–12.

Takada Y, Arai T, Kashihara T, Asakura H, Mizuno R, Murayama S, et al. Relationship between Distance from the Superior Border of Irradiation Field to the Aortic Bifurcation and Non- Regional Lymph Node Recurrence after Definitive Radiotherapy in Uterine Cervical Cancer.

Webster A, Appelt AL, Eminowicz G. Image-guided radiotherapy for pelvic cancers: a review of current evidence and clinical utilisation. Clinical Oncology. 2020;32(12):805-16.